Neuroscience Lecture by Antoine Triller (Institut de Biologie de l’Ecole Normale Supérieure, Paris, France)

Title: "Super-resolutive and single molecule imaging: a new view on synapse biology"

Antoine Triller

Time and venue: 11.00 a.m. at the Lecture Hall (room 0.10 of the Max Planck Institute of Biophysics, Max-von-Laue-Str. 3, 60438 Frankfurt am Main, Campus Riedberg)

Single molecule imaging has emphasized that synapses are not static entities but result from the continuous assembly and disassembly of molecules. Furthermore, single molecule and super-resolution imaging allows an access to molecular interactions that are implicated within the synapse. Measuring association and dissociation rates and determining equilibrium constants is particularly important for the investigation of supra-molecular structures such as the synapse, which represent a mesoscale intermediate between the molecular and the cellular scale. Using a combination of dynamic imaging and biochemical approaches we have characterized the molecular mechanisms that link the inhibitory glycine and GABA receptor-gephyrin interaction with their diffusion and their number at synapses. I will present recent results in relation with the plasticity of inhibition.



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