Neuroscience Lecture by Claudia Bagni (Center for Human Genetics, K.U. Leuven - V.I.B., Belgium and Department of Biology, Universita' di Roma, Tor Vergata, Italy)

Title: "Molecular plasticity in the context of The Fragile X Syndrome"

Claudia Bagnia

Time and venue: 11.00 a.m. at the Lecture Hall of the Max Planck Institute for Brain Research, Max-von-Laue-Str. 4, 60438 Frankfurt am Main, Campus Riedberg

Abstract: Fragile X Syndrome (FXS) is the most frequent form of inherited intellectual disability and is also linked to other neurological, neurodegenerative and psychiatric disorders. FXS is caused by a triplet expansion that inhibits expression of the FMR1 gene; the gene product, FMRP, regulates mRNA metabolism in the brain and thus controls the expression of key molecules involved in receptor signaling and spine morphology. While there is no definitive cure for FXS, the understanding of FMRP function has paved the way for rational treatment designs that could potentially reverse many of the neurobiological changes observed in FXS. Additionally, behavioral, pharmacological and cognitive interventions can raise the quality of life for both patients and their families.

Host: Prof. Erin Schuman (MPI for Brain Research)
Co-Host: Prof. Alexander Heckel (Goethe University)

Host: Prof. Erin Schuman, Max Planck Institute for Brain Research
Co-Host: Prof. Harald Schwalbe, Center of Excellence Frankfurt, Macromolecular Complexes



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