Neuroscience Lecture by Jernej Ule (Department of Molecular Neuroscience, Institute of Neurology, University College London)

Title: "Structure and function of RNA-protein interactions, and their role in disease and evolution"

Jernej Ule

Time and venue: 11.00 a.m. at the Lecture Hall of the Max Planck Institute for Brain Research, Max-von-Laue-Str. 4, 60438 Frankfurt am Main, Campus Riedberg

Abstract: Protein-RNA interactions play an essential role in regulating the fate of mRNAs in cells. In the first part of my talk, I will present a new technology to identify RNA structures interacting with double-stranded RNA binding proteins (dsRBPs). This technology employs RNA hybridization, individual-nucleotide resolution UV cross-linking and immunoprecipitation and high-throughput sequencing (hiCLIP). We used hiCLIP to study RNA structures recognized by Staufen 1 (STAU1), a dsRBP that controls RNA localization in a variety of cell types, including neurons. We found that STAU1 binds RNA structures that can form either by short-range and long-range RNA-RNA interactions. I will present how STAU1 binds these RNA structures to control mRNA localization, stability and translation. In the second part, I will show how multiple RNA-binding proteins compete for overlapping sites on nascent RNAs. This competition controls the formation of exons, and mutations that modify this competition either lead to disease, or to evolution of new exons.



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