Neuroscience Lecture by Joshua Kaplan (Massachusetts General Hospital, Simches Research Ctr, Boston, USA)

Title: "Tuning the kinetics of synaptic responses: mechanisms regulating release kinetics in C. elegans."

Joshua Kaplan

Time and venue: 11.00 a.m. at the Lecture Hall (room 0.10 of the Max Planck Institute of Biophysics, Max-von-Laue-Str. 3, 60438 Frankfurt am Main, Campus Riedberg)

Our behaviors and our thoughts are encoded by the temporal pattern of activity in the brain. Consequently, perturbations that alter the kinetics of neuronal responses will have profound effects on cognition and behavior. In my talk, I will discuss our efforts to understand mechanisms regulating the kinetics of neurotransmitter release at synapses.  In particular, we find that fast and slow release represent independent exocytosis mechanisms that operate in parallel. In addition, we find that mutations linked to autism spectrum disorders (ASD) alter release kinetics. Thus, changes in release kinetics may represent an important pathological mechanism that contributes to the developmental and cognitive changes that occur in ASD.



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