Special Lecture by Botond Roska (Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland)
Title: Cell types, circuits and repair
Time and venue: 11.00 a.m. at the Lecture Hall (room 0.10 of the Max Planck Institute of Biophysics, Max-von-Laue-Str. 3, 60438 Frankfurt am Main, Campus Riedberg)
The retina can be viewed as a parallel image processor that acquires images with its mosaic of photoreceptors, and uses its internal neuronal circuits to compute more than a dozen neural representations of the visual world. I will discuss three topics related to retinal cell types, circuits and repair. First, using a library of mice with selectively labeled retinal cell types we created a cell type comparative transcriptome atlas. I show that cell types express few, type-specific transcription factors, suggesting a transcription factor-based code. Second, I discuss how circuit asymmetry develops in genetically identified retinal circuits. Third, I will demonstrate that the understanding of cell types and computations in combination with optogenetic tools can lead to a rational strategy to restore visual function in the blinding disease retinitis pigmentosa.
Dr. Arjan Vink
T: +49 69 850033-2900
M: +49 175 2647988