The amazing journey of AMPA-type glutamate receptors / Understanding memory at the molecular level.
The global aging of populations in our societies is imposing new challenges for public health. In the U.S. a collection of data shows that 20% of the population over 65 years old suffers from mild to severs forms of cognitive and memory deficits. Thus, it is crucial to understand the mechanisms of memory formation in the brain to ultimately design strategies to defy age-related impairments.
In the central nervous system, each neuron can form up to 10.000 connections with other neurons also known as synapses. The memory capacity of the brain comes from the ability of neurons to modify the strength of their connections depending on their use. The number of AMPA-type glutamate receptors (AMPARs) at a given synapse defines the strength of the synapse. By adjusting the number of AMPARs in synapses neurons can adapt single synapse strength in function of previous activity. During this talk, we will explore the journey of AMPARs from their site of synthesis to the synapse in order to understand how neurons store information.
Dr. Anne-Sophie Hafner studied Neuroscience in Paris. After an intership at New York University she moved to Bordeaux (France) for her PhD. She studied the molecular mechanism responsible for the stabilisation of receptors at excitatory synapses. Since 2015, she works in the laboratory of Erin Schuman to understand the role of differential translation location on the composition of receptors.
Dr. Or Shahar
Postdoc at the Schuman Department
Dr. Arjan Vink
T: +49 69 850033 2900
M: +49 175 2647988