Computation in Neural Circuits - Gjorgjieva Group

Efficient transmission of information across neural circuits requires an intricate balance between the intrinsic properties of single neurons and the synaptic connections between them. How are neurons and networks tuned to achieve this balance and enable the emergence of reliable computation? We are interested in two aspects of circuit organization: how it comes about from the interaction of single neuron properties and synaptic plasticity (as during learning and circuit development); and the organization principles that achieve it over the longer timescale of evolution.

Our work is based on computational and mathematical approaches to understand how activity, generated spontaneously in the circuit, or by the external environment, shapes network organization and dynamics. We study the interaction of a diversity of mechanisms, including synaptic plasticity, intrinsic cellular properties, sensory noise, and biophysical constraints, on the generation of adult function and computation.

Our work is supported by close experimental collaborations based on different animal models, from rodent to fruit fly, allowing direct access to individual neural circuit components. Computational and theoretical approaches allow us to study in a principled way how multiple processes, acting at the level of individual neurons or their synaptic connections, coordinate their action to organize circuit properties. Thus, our models provide a testbed for exploring novel stimuli and directing future experiments that will allow for the right neuronal populations to be recorded and manipulated.

Specific interests include:

  • Using information theoretic and statistical inference approaches to understand the diversity of sensory population responses
  • Connecting single cell properties to network dynamics in the developing mammalian cortex
  • Exploring the interaction of synaptic plasticity rules during network homeostasis
  • Examining the relationship between neural circuits for crawling in Drosophila larvae and different behavioral strategies used during exploration



Upcoming Lectures and Events

04 March 2021

mpibr External Postdoctoral Seminar Concatenations by Heike Blockus (Columbia University (New York)

Title: Synaptogenic activity of the axon guidance molecule Robo2 is critical for hippocamp... [more]

10 March 2021

Neuroscience Online Lecture by Ilaria Testa (Advanced Optical Bio-Imaging Laboratory Science for Life Laboratory, KTH Karolinska Institutet Science Park, Stockholm)

Title: A new look in the interior of cells with 3D MoNaLISA nanoscopy [more]

30 March 2021

Connecting Brains Lecture by André Fenton (New York University, New York, USA)

Title: Learning to Learn, across biological scales [more]

31 March 2021

Neuroscience Lecture by Emily Osterweil (Centre for Discovery Brain Sciences University of Edinburgh)

Title: The long and short of altered translation in Fragile X [more]

07 April 2021

Neuroscience Online Lecture by Naoshige Uchida (Center for Brain Science, Harvard University Cambridge, USA)

Title: Diversity of dopamine neurons: multiple axes and vector prediction errors [more]