A new program for neural stem cells

Max Planck researchers succeed in obtaining brain and spinal cord cells from stem cells of the peripheral nervous system

May 04, 2011

Neural stem cells can do a lot, but not everything. For example, brain and spinal cord cells are not usually generated by neural stem cells of the peripheral nervous system, and it is not possible to produce cells of the peripheral nervous system from the stem cells of the brain. However, researchers from the Max Planck Institute for Brain Research in Frankfurt and the Max Planck Institute of Immunobiology and Epigenetics in Freiburg have now succeeded in producing central nervous system cells from neural stem cells of the peripheral nervous system. They found that if peripheral stem cells are maintained under defined growth conditions, they generate oligodendrocytes, which form the myelin layer that surrounds the neurons found in the brain and spinal cord.

A new program for neural stem cells
Transplantation of reprogrammed neural stem cells into the brains of genetically modified mice, which cannot form myelin. The stem cells develop oligodendrocytes (green), which form myelin (red). (c) MPI for Brain Research more
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