Publications of B. Laube

Dutertre, S.; Drwal, M.; Laube, B.; Betz, H.: Probing the pharmacological properties of distinct subunit interfaces within heteromeric glycine receptors reveals a functional beta beta agonist-binding site. Journal of Neurochemistry 122 (1), pp. 38 - 47 (2012)

Kallenborn-Gerhardt, W.; Lu, R.; Lorenz, J.; Gao, W.; Weiland, J.; Del Turco, D.; Deller, T.; Laube, B.; Betz, H.; Geisslinger, G. et al.; Schmidtko, A.: Prolonged zymosan-induced inflammatory pain hypersensitivity in mice lacking glycine receptor alpha2. Behavioral Brain Research 226, pp. 106 - 111 (2012)

Haeger, S.; Kuzmin, D.; Detro-Dassen, S.; Lang, N.; Kilb, M.; Tsetlin, V.; Betz, H.; Laube, B.; Schmalzing, G.: An intramembrane aromatic network determines pentameric assembly of Cys-loop receptors. Nature Structural & Molecular Biology 17 (1), pp. 90 - 98 (2010)

Madry, C.; Betz, H.; Geiger, J. R. P.; Laube, B.: Potentiation of glycine-gated NR1/NR3A NMDA receptors relieves Ca2+-dependent outward rectification. Frontiers in Molecular Neuroscience 3, 6 (2010)

Maksay, G.; Laube, B.; Schemm, R.; Grudzinska, J.; Drwal, M.; Betz, H.: Different binding modes of tropeines mediating inhibition and potentiation of alpha 1 glycine receptors. Journal of Neurochemistry 109 (6), pp. 1725 - 1732 (2009)

Schumann, T.; Grudzinska, J.; Kuzmin, D.; Betz, H.; Laube, B.: Binding-site mutations in the alpha 1 subunit of the inhibitory glycine receptor convert the inhibitory metal ion Cu2+ into a positive modulator. Neuropharmacology 56 (1), pp. 310 - 317 (2009)

Madry, C.; Betz, H.; Geiger, J. R. P.; Laube, B.: Supralinear potentiation of NR1/NR3A excitatory glycine receptors by Zn2+ and NR1 antagonist. Proceedings of the National Academy of Sciences of the United States of America 105 (34), pp. 12563 - 12568 (2008)

Schumann, T.; Grudzinska, J.; Betz, H.; Laube, B.: Binding-site mutaions in the α1 subunit of the inhibitory glycine receptor convert the inhibitory metal ion Cu²⁺ into a positive modulator. Neuropharmacology 56, pp. 310 - 317 (2008)

Madry, C.; Mesic, I.; Betz, H.; Laube, B.: The N-terminal domains of both NR1 and NR2 Subunits determine allosteric Zn2+ inhibition and glycine affinity of N-methyl-d-aspartate receptors. Molecular Pharmacology 72 (6), pp. 1535 - 1544 (2007)

Papadopoulos, T.; Korte, M.; Eulenburg, V.; Kubota, H.; Retiounskaia, M.; Harvey, R. J.; Harvey, K.; O'Sullivan, G. A.; Laube, B.; Huelsmann, S. et al.; Geiger, J. R. P.; Betz, H.: Impaired GABAergic transmission and altered hippocampal synaptic plasticity in collybistin-deficient mice. EMBO Journal 26 (17), pp. 3888 - 3899 (2007)

Madry, C.; Mesic, I.; Bartholomäus, I.; Nicke, A.; Betz, H.; Laube, B.: Principal role of NR3 subunits in NR1/NR3 excitatory glycine receptor function. Biochemical and Biophysical Research Communications 354 (1), pp. 102 - 108 (2007)

Maier, W.; Schemm, R.; Grewer, C.; Laube, B.: Disruption of interdomain interactions in the glutamate binding pocket affects differentially agonist affinity and efficacy of N-methyl-D-aspartate receptor activation. Journal of Biological Chemistry 282 (3), pp. 1863 - 1872 (2007)

Laube, B.: Dr. Jekyll & Mr. Hide - das janusköpfige Zink. Bioforum 30 (3), pp. 25 - 27 (2007)

Betz, H.; Laube, B.: Glycine receptors: recent insights into their structural organization and functional diversity. Journal of Neurochemistry 97, pp. 1600 - 1610 (2006)

Hirzel, K.; Müller, U.; Latal, A. T.; Hülsmann, S.; Grudzinska, J.; Seeliger, M. W.; Betz, H.; Laube, B.: Hyperekplexia phenotype of glycine receptor alpha 1 subunit mutant mice identifies Zn2+ as an essential endogenous modulator of glycinergic neurotransmission. Neuron 52 (4), pp. 679 - 690 (2006)

Maier, W.; Schemm, R.; Grewer, C.; Laube, B.: Disruption of interdomain interactions in the glutamate binding pocket affects differentially agonist affinity and efficacy of NMDA receptor activation. Journal of Biological Chemistry 282, pp. 1863 - 1872 (2006)

Chandra, T.; Maier, W.; König, H. G.; Hirzel, K.; Kögel, D.; Schüler, T.; Chandra, A.; Demirhan, I.; Laube, B.: Molecular interactions of the HIV-1 Tat protein with NMDA receptor subunits. Neuroscience 134 (1), pp. 145 - 153 (2005)

Grudzinska, J.; Schemm, R.; Haeger, S.; Nicke, A.; Schmalzing, G.; Betz, H.; Laube, B.: The beta subunit determines the ligand binding properties of synaptic glycine receptors. Neuron 45 (5), pp. 727 - 739 (2005)

Kondratskaya, E. L.; Betz, H.; Krishtal, O. A.; Laube, B.: The beta subunit increases the ginkgolide B sensitivity of inhibitory glycine receptors. Neuropharmacology 49 (6), pp. 945 - 951 (2005)

Maier, W.; Corrie, J. E. T.; Papageorgiou, G.; Laube, B.; Grewer, C.: Comparative analysis of inhibitory effects of caged ligands for the NMDA receptor. Journal of Neuroscience Methods 142 (1), pp. 1 - 9 (2005)